Correlation of serum interleukin-6 levels and neutrophil-lymphocyte ratio in the severity of COVID-19

Background: Interleukin-6 (IL-6) is a pro-inflammatory cytokine that produced at varying levels in patients with coronavirus disease 2019 (COVID-19). The neutrophil–lymphocyte ratio (NLR) one of the new inflammatory markers COVID-19. This study aimed to evaluate differences IL-6 level and NLR mild severe COVID-19 assess their correlation severity COVID-19. Methods: A total 91 were divided into (n = 57) 34) groups. measured using electrochemiluminescence immunoassay method on Roche Cobas e411. was neutrophil lymphocyte counts from complete haematology Sysmex XS-800i. Data analysed Kolmogorov–Smirnov, Mann–Whitney, receiver operating characteristic curve, chi-square Spearman tests. statistical test significant p <0.05. Results: Serum significantly differed median (min–max) for 3.59 (1.50–638.30) pg/mL 28.82 (5.52–926.30) pg/mL, respectively (p <0.001). moderate 2.18 (0.69–15.58) 8.13 (2.24–30.90), obtained cut-off values >6.99 >4.18, odds ratios 29.29 26.19, respectively. positive found between (r 0.612; <0.001). Conclusions: results indicated serum are higher than Patients >4.18 29 26 times more likely suffer COVID-19, strongly correlated severity. correlate COVID-19.